Differing clinical impact ofBRCA1andBRCA2mutations in serous ovarian cancer
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چکیده
منابع مشابه
New insights into the pathogenesis of serous ovarian cancer and its clinical impact.
There are only a handful of concepts concerning cancer and carcinogenesis that are currently beyond dispute. One such dogma is the adenoma-carcinoma sequence and that a multistep accumulation of genetic alterations is required for transformation from a benign to a neoplastic tissue. The inevitable derivative of this dogma is that every invasive carcinoma is in fact a missed intraepithelial tumo...
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Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors. While cytoreductive surgery followed by platinum based chemotherapy are initially effective, ovarian tumors have a high propensity to recur highlighting the distinct need for novel therapeutics to improve outcomes for affected w...
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Background:Diagnosis of ovarian mass during pregnancy may be postponed because they may mimic physiological signs of pregnancy. Ovarian masses can lead to complications such as overgrowth, torsion or cyst rupture. Therefore, to inform health providers concerning symptoms, safe diagnostic methods and proper management seem appropriate. Case report: A 19-year-old primigravida was presented to our...
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Objective: To investigate the therapeutic effect of secondary cytoreductive surgery in the patients with low grade serous ovarian cancer and to analyze the influence of the postoperative quality of life. Method: We collected the clinical data of patients with low grade serous carcinoma who underwent secondary cytoreductive surgery in our hospital from January 2003 to January 2015, and performed...
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Genome sequencing technologies and corresponding oncology publications have generated enormous publicly available datasets for many cancer types. While this has enabled new treatments, and in some limited cases lifetime management of the disease, the treatment options for serous ovarian cancer remain dismal. This review summarizes recent advances in our understanding of ovarian cancer, with a f...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2012
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.12.137